As we age, our natural ability to modulate inflammation, support neurons and prevent tumorigenesis wanes. Cellular aging is directly tied to the cell’s decreasing ability to generate NAD+ (nicotinamide adenine dinucleotide). NAD+ is the intracellular fuel required for enzymes to work and is a cofactor to an important mitochondrial enzyme, Sirt3.

Sirt3 activates many molecular signals of cellular respiration, the most vital of all cellular functions. Sirt3 is present in the mitochondria, nucleus and cytosol of every mammalian cell and in all tumor cells. How does all this science come together? Honokiol, a natural product extracted from Magnolia bark, upregulates Sirt3.

That means Viv is a major molecular mediator of anti-aging, anti-inflammation, and neuronal protection. But that's not all. Here's all the research on the benefits of Viv in one place.

Honokiol in cancer:

Inhibits bone metastases in prostate cancer

Potentiates breast cancer hormonal treatment effects in obese patients 

Suppresses pancreatic cancer growth and metastasis 

Promotes degradation  tumorgenic molecular fusion proteins in a subset of acute myeloid leukemia 

Inhibits melanoma stem cells 

Prevents liver cancer by decreasing fatty liver disease 

Honokiol in prevention of neurodegeneration:

Increases gut neural survival 

Improves cognition in Alzheimer’s disease 

Improves cognition in Alzheimer's disease (02)

Improves learning and memory impairment 

Improves and reverses motor impairments in Parkinson’s 

Improves and reverses motor impairments in Parkinson's (02)

Honokiol in decreasing inflammation:

Alleviates inflammation in osteoarthritis 

Alleviates inflammation in osteoarthritis (02)

Alleviates inflammation in osteoarthritis (03)

Improves psoriasis, a common inflammatory skin disease 

Improves psoriasis, a common inflammatory skin disease (02)

Decreases fatty liver disease/NASH (nonalcoholic steatohepatitis)

Decreases fatty liver disease/NASH (nonalcoholic steatohepatitis) (02)

Honokiol in decreasing fibrosis: 

Decreases skin and systemic sclerosis (skin scleroderma and a debilitating systemic fibrosing disease) 

Improves pulmonary fibrosis 

Improves pulmonary fibrosis (02)

Improves cardiac fibrosis and alleviates chemotherapy induced cardiac toxicity  

Improves cardiac fibrosis and alleviates chemotherapy induced cardiac toxicity (02)

Honokiol as a potent antiviral:

Inhibits Covid viral replication after virus infects cells  

Inhibits HIV viral replication  

Chemoprevention of Human Papilloma virus driven oral cancer 

Honokiol as an anti-hypertension agent:

Improves hypertension by Sirt3 mediated relaxation of blood vessel wall 

Improves hypertension by Sirt3 mediated relaxation of blood vessel wall (02)

Improves hypertension by Sirt3 mediated relaxation of blood vessel wall (03)

Honokiol in preventing vision & hearing loss:

Inhibits pathologic blood vessel growth and degeneration in macular degeneration/ocular diseases

Inhibits pathologic blood vessel growth and degeneration in macular degeneration/ocular diseases (02)

Prevents natural and chemotoxicity associated hearing loss